Aim

The goal of this task is to validate that the Digital Patient can be utilized for routine dose planning in prostate and cervix cancer radiation therapy. The feasibility of creating EBRT and BT dose distributions in accordance with heterogeneous dose prescriptions guided by functional imaging will be validated. Furthermore, the infrastructure for integrating the complete procedure of imaging, dose prescription and dose planning will be evaluated in terms of feasibility and workload in a multicenter setting.

Approach

The impact of geometrical uncertainties and the impact of variations in imaging over time will be evaluated in order to assess the robustness of heterogeneous dose distributions. The validation will be performed in both prostate and cervix cancer and for EBRT as well as for BT. In a next step, a multicenter evaluation will be performed to evaluate the workflow developed in DR THERAPAT and to assess the workload related to the entire chain from multimodality imaging to the treatment plan.

Expected outcome

DR THERAPAT will demonstrate that it is practically feasible to create heterogeneous dose distributions which direct increased dose to radioresistant regions as defined based on multimodality MRI. DR THERAPAT will demonstrate that routine dose planning based on multimodality MRI is feasible in a multicenter setting.

Illustration

Aarhus Figure

Brachytherapy focal boosting in cervix cancer. The residual tumour (red contour) after EBRT is targeted with >90Gy.