Scientific publications by the project

S. Rylander, D.Polders, M.J. Steggerda, L.M. Moonen, K. Tanderup, U.A. Van der Heide, Re-distribution of brachytherapy dose using a differential dose prescription adapted to risk of local failure in low-risk prostate cancer patients, Radiotherapy and Oncology, 2015.

O. Casares-Magaz, M. Thor, D. Liao, J.B. Frøkjær, P. Kræmer, K. Krogh, A.M. Drewes, H. Gregersen, V. Moiseenko, M. Høyer, L.P. Muren, An image-based method to quantify biomechanical properties of the rectum in radiotherapy of prostate cancer, Acta Oncol, Jul 22:1-8, 2015.

O. Casares-Magaz, U.A. van der Heide, J. Rørvik, P. Steenbergen and LP. Muren, A tumor control probability model for radiotherapy of prostate cancer using magnetic resonance imaging-based apparent diffusion coefficient maps, Radiotherapy & Oncology, in press.

K. Tanderup, L.U. Fokdal, A. Sturdza, C. Haie-Meder, R. Mazeron, E. van Limbergen, I. Jürgenliemk-Schulz, P. Petric, P. Hoskin, W. Dörr, S.M. Bentzen, C. Kirisits, J.C. Lindegaard, R. Pötter, Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer, Radiotherapy & Oncology, in press.

S. Haack, K. Tanderup, J.F. Kallehauge, S.M. Mohamed, J.C. Lindegaard, E.M. Pedersen, S.N. Jespersen, Diffusion-weighted magnetic resonance imaging during radiotherapy of locally advanced cervical cancer–treatment response assessment using different segmentation methods, Acta Oncol 54(9): 1535-42, 2015.

S. Haack, J.F. Kallehauge, S.N. Jespersen, J.C. Lindegaard, K. Tanderu, E.M. Pedersen, Correction of diffusion-weighted magnetic resonance imaging for brachytherapy of locally advanced cervical cancer, Acta Oncol 53(8): 1073-8, 2015.

J.F. Kallehauge, K. Tanderup, C. Duan, S. Haack, E.M. Pedersen, J.C. Lindegaard, L.U. Fokdal, S.M. Mohamed, T. Nielsen, Tracer kinetic model selection for dynamic contrast-enhanced magnetic resonance imaging of locally advanced cervical cancer, Acta Oncol 53(8): 1064-72, 2015.

U.A. van der Heijde, The issue of multi-center comparison of imaging data, Proceedings ESTRO34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Vol. 115, S147–S148, 2015

C. Dinh, K. Haustermans, .P Steenbergen, G. Ghobadi, E. Lerut, R. Oyen, H. van de Poel, L. de Jong, S. Heijmink, U.A. van der Heide, Multi-center validation of a model for prostate tumor delineation using multi-parametric MRI, Proceedings ESTRO 34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Volume 115, Supplement 1, Page S38, 2015.

G. Ghobadi, J. De Jong, B.G. Hollmann, B. Van Triest, H.G. Van der Poel, C. Vens, U.A. Van der Heide, Pathology of CTV of prostate cancer: implications for the dose to the tumor and the gland, Proceedings ESTRO34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Vol. 115, S351, 2015.

V.C. Dinh, K. Haustermans, P. Steenbergen, G. Ghobadi, E. Lerut, R. Oyen, H. Van der Poel, J. de Jong, S. Heijmink, U.A> van der Heide. Multi-center validation of a model for prostate tumor delineation using multi-parametric MRI, Proceedings ESTRO34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Vol. 115, 2015.

M. Frantzen-Steneker, Routine QA of an MR-only workflow, Proceedings ESTRO34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Vol. 115, S12, 2015.

S. Rylander, D. Polders, M.J. Steggerda, L.M. Moonen, K. Tanderyp, U.A. van der Heijde, A differential target and dose prescription strategy in permanent low-dose-rate prostate brachytherapy, Proceedings ESTRO34, 24-28 April 2015, Barcelona, Spain, Radiotherapy and Oncology, Vol. 115, S114, 2015.

U.A. van der Heijde, MRI for functional definition, RSNA Oral RC122B, 29 November – 3 December 2015, Chicago, USA.

U.A. van der Heijde, Imaging needs for radiation therapy, Proceedings ISMRM 2015, 30 May – 5 June 2015, Toronto, Canada.

U.A. van der Heijde, Recent developments in quantitative imaging for radiotherapy, 13th Acta Oncologica Symposium Biology-Guided Adaptive Radiotherapy (BIGART), Aarhus, Denmark – June 10-12, 2015.

K. Tanderup, L.U. Fokdal, A.E. Sturdza, R. Mazeron, C. Kirisits, J.C. Lindegaard, W. Dörr, R. Pötter Dose and volume response for local control in locally advanced cervical cancer treated with EBRT combined with MRI guided adaptive brachytherapy, Proceedings ASTRO 2015, Radiation Oncology 90(1)Supplement: S91-S92.

G. Ghobadi, J. de Jong, B.G. Hollmann, B. van Triest, H.G.van der Poel, C. Vens, U.A. van der Heide, Histopathology-derived modeling of prostate cancer tumor control probability: Implications for the dose to the tumor and the gland, Radiother Oncol. 2016 Feb 16: S0167-8140 (Epub ahead of print].

L.D. van Buuren, D. Polders, M. Milder, U.A. van der Heide, The impact of MR in radiotherapy for treatment follow-up, Proceedings 3rd MR in RT Symposium, 16-17 June 2015, Lund, Sweden.

S. Renisch, H. Schulz, M. Köhler, M. Helle, M. Frantzen-Steneker, U.A. van der Heide3, Validation of MR-based density maps for radiation treatment planning of the pelvis, Proceedings 3rd MR in RT Symposium, 16-17 June 2015, Lund, Sweden.

P.J. van Houdt, H.K. Agarwal, L.D. van Buuren, M. Ivancevic, G. Ghobadi, F. Pos, U.A. van der Heide, Validation of k-t T2 mapping for treatment response monitoring, Proceedings 3rd MR in RT Symposium, 16-17 June 2015, Lund, Sweden.

E.M.E. Klawer, P.J. van Houdt, F.J. Pos, H.J. Teertstra, UA van der Heide1, Reproducibility of arterial input function of DCE-MRI in prostate cancer: influence of varying injection duration, Proceedings 3rd MR in RT Symposium, 16-17 June 2015, Lund, Sweden.

S. Weiss, C. Stehning, A. Halkola, Quantification of geometric errors for MR-based radiation therapy planning in prostate, Proceedings 3rd MR in RT Symposium, 16-17 June 2015, Lund, Sweden

A. Vilanova, Visual Analysis for Hypothesis Generation in Medical Imaging Research, MedViz Conference, 15-16 June 2015, Bergen, Norway.

PJ. van Houdt, HK. Agarwal, LB. van Buuren, M. Ivancevic, S. Haack, J.F. Kallehauge, P.L. Choyke, U.A. van der Heide, Validation of T2 mapping for treatment response monitoring in longitudinal multi-center clinical trials, Proceedings ISMRM 2015, 30 May – 5 June 2015, Toronto, Canada.

S. Rylander, D.Polders, M.J. Steggerda, L.M. Moonen, K. Tanderup, U.A. Van der Heide, “Re-distribution of brachytherapy dose using a differential dose prescription adapted to risk of local failure in low-risk prostate cancer patients”, Radiotherapy and Oncology 2015 (in press).

O. Casares-Magaz, M. Thor, D. Liao, J.B. Frøkjær, P. Kræmer, K. Krogh, A.M. Drewes, H. Gregersen, V. Moiseenko, M. Høyer, L.P. Muren, “An image-based method to quantify biomechanical properties of the rectum in radiotherapy of prostate cancer”, Acta Oncol. 2015 Jul 22:1-8. [Epub ahead of print].

C. A. Kyroudis, D. D. Dionysiou, E. A. Kolokotroni, J. F. Kallehague, K. Tanderup and G. S. Stamatakos, “Simulation of Cervical Cancer Response to Radiotherapy.” In G. Stamatakos and D. Dionysiou (Eds): Proc. 2014 6th Int. Adv. Res. Workshop on In Silico Oncology and Cancer Investigation – The CHIC Project Workshop (IARWISOCI), Athens, Greece, Nov.3-4, 2014 (www.6th-iarwisoci.iccs.ntua.gr), pp.39-42. (open-access version), ISBN: 978-618-80348-1-5.

S. Haack, J.F. Kallehauge, S.N. Jespersen, J.C. Lindegaard, K. Tanderup and E.M. Pedersen, Correction of diffusion-weighted magnetic resonance imaging for brachytherapy of locally advanced cervical cancer, Acta Oncologica, 2014; 53: 1073–1078.

N. Schadewaldt, H. Schulz, M. Helle, M. Frantzen-Steneker, U.A. van der Heide and S. Renisch, Comparison of Dose Calculation On Automatically Generated MR-Based ED Maps and Corresponding Patient CT for Clinical Prostate EBRT Plans, Proceedings AAPM, Austin, Texas, USA, 2014.

R.G. Raidou, U.A. van der Heide, P.J. van Houdt, M. Breeuwer and A. Vilanova, The iCoCooN: Integration of Cobweb Charts with Parallel Coordinates for Visual Analysis of DCE-MRI Modeling Variations, Eurographics Workshop on Visual Computing for Biology and Medicine, page 11-20, 2014.

S. Rylander, D. Polders, M.J. Steggerda, L.M. Moonen, K. Tanderup and U.A. van der Heide, Focal therapy to prostatic tumour lesion using LDR- or HDR brachytherapy technique, ESTRO 33, Vienna, Austria, 2014.

G. Ghobadi, B.G. Hollmann, J.E. de Jong, H.G. van der Poel, B. van Triest and U.A. van der Heide, Pathology of CTV of prostate cancer: implications for the dose to the tumor and the gland, ESTRO 33, Vienna, Austria, 2014.

M. Frantzen-Steneker, M. Helle, H. Schulz, S. Renisch, N. Schadewaldt, A. Wolf, R. Rozendaal, S. van Kranen, E. Alpay and U.A. van der Heide, In-vivo dosimetric evaluation of an atlas based labeling technique using MR DIXON for MR-only RT treatment planning, ESTRO 33, Vienna, Austria, 2014.

P. Steenbergen, K. Haustermans, F.J. Pos, R. Oyen, S.W. Heijmink, L. De Wever, R. Kalisvaart, H.J. Teertstra, L. Van den Bergh and U.A. van der Heide, Prostate tumor delineation using multiparametric MRI inter-observer variability and pathology validation, ESTRO 33, Vienna, Austria, 2014.

A. Elen, C. Wouter, I. Sofie, K. Haustermans and F. Maes, Impact of CT-MR registration imprecision on treatment planning for prostate cancer. ESTRO 33, Vienna, Austria, 4-8/04/2014 (oral presentation). Radiother Oncol 2014;111(Suppl1):76 (OC-0168).

A. Elen, W. Crijns, S. Isebaert, K. Haustermans and F. Maes, Impact of registration imprecision on dose delivery in the presence of a boost region, ESTRO 33, Vienna, Austria, 2014.

M. Frantzen-Steneker, M. Helle, H. Schulz, S. Renisch, N. Schadewaldt, A. Wolf, R. Rozendaal, S. Van Kranen, E. Alpay and U.A. van der Heide, In-vivo dosimetric evaluation of an atlas based labeling technique using a DIXON MRI sequence for MR-only radiotherapy treatment planning,  ESTRO 33, Vienna, Austria, 2014.

S.K. Nielsen, L. Fokdal, J. Lindegaard, J.F. Kallehauge, S. Haack, E.M. Pedersen and K. Tanderup, Diffusion weighted MRI and GTV at time of brachytherapy in locally advanced cervical cancer, Estro 33, Vienna, Austria, 2014.

J. Kallehauge, S. Haack, K. Tanderup, J.C. Lindegaard, S. Mohamed, E.M. Pedersen, L. Fokdal and T. Nielsen, Tracer kinetic model selection for dynamic contrast-enhanced MRI of locally advanced cervical cancer, Estro 33, Vienna, Austria, 2014.

C. Mariager, K. Tanderup and J. Kallehauge, Relaxation parameter estimation and comparison of NLS and LLS methods in the cervix, Estro 33, Vienna, Austria, 2014.

S. Haack, K. Tanderup, J.F. Kallehauge, J.C. Lindegaard, E.M. Pedersen and S.N. Jespersen, Diffusion weighted MRI for radiotherapy treatment of locally advanced cervical cancer – treatment response assessment using different segmentation methods, Abstract 4269, Proceedings ISMRM, Milano, Italy, 2014.

M. Helle, N. Schadewaldt, M. Frantzen-Steneker, H. Schulz, C. Stehning, U.A. van der Heide and S. Renisch, Evaluation of Dixon based Soft Tissue and Bone Classification in the Pelvis for MR-only-based Radiation Therapy Planning, Abstract 4238, Proceedings ISMRM, Milano, Italy, 2014.

J. Kallehauge, T. Nielsen, S. Haack, D.A. Peters , S. Mohamed, L. Fokdal, J.C. Lindegaard, D.C. Hansen, F. Rasmussen, K. Tanderup and E.M. Pedersen, Voxelwise comparison of perfusion parameters estimated using dynamic contrast enhanced (DCE) computed tomography and DCE-magnetic resonance imaging in locally advanced cervical cancer, Acta Oncol. 2013 Oct;52(7):1360-8.

S. Haack, K. Tanderup, J.F. Kallehauge, S.N. Jespersen and E.M. Pedersen, Diffusion Weighted MRI acquisition with high acceleration factor for improving accuracy for use in radiotherapy planning, BIGART, Aarhus, Denmark, 2013.

S. Haack, K. Tanderup, L. Fokdal, J.F. Kallehauge, J.C. Lindegaard, S.N. Jespersen and E.M. Pedersen, Diffusion Weighted MRI as a predictive tool for effect of radiotherapy in locally advanced cervical cancer, Abstract 4730 Proceedings ISMRM, Salt Lake City, USA, 2013.

Interesting other scientific publications

Residual tumour volumes and grey zones after external beam radiotherapy (with or without chemotherapy) in cervical cancer patients. A low-field MRI study.
Schmid MP, Mansmann B, Federico M, Dimopoulous JC, Georg P, Fidarova E, Dörr W, Pötter R.
Strahlenther Onkol. 2013 Mar;189(3):238-44. doi: 10.1007/s00066-012-0260-7. Epub 2013 Jan 25.

Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer.
Pötter R, Georg P, Dimopoulos JC, Grimm M, Berger D, Nesvacil N, Georg D, Schmid MP, Reinthaller A, Sturdza A, Kirisits C.
Radiother Oncol. 2011 Jul;100(1):116-23. doi: 10.1016/j.radonc.2011.07.012. Epub 2011 Aug 5.

Adaptive management of cervical cancer radiotherapy.
Tanderup K, Georg D, Pötter R, Kirisits C, Grau C, Lindegaard JC.
Semin Radiat Oncol. 2010 Apr;20(2):121-9. doi: 10.1016/j.semradonc.2009.11.006. Review.

From point A to the sculpted pear: MR image guidance significantly improves tumour dose and sparing of organs at risk in brachytherapy of cervical cancer.
Tanderup K, Nielsen SK, Nyvang GB, Pedersen EM, Røhl L, Aagaard T, Fokdal L, Lindegaard JC.
Radiother Oncol. 2010 Feb;94(2):173-80. doi: 10.1016/j.radonc.2010.01.001.

Multiscale cancer modeling.
Edited by Tomas Deisboeck and Georgios S . Stamatakos.
CRC Press 2010, Print ISBN: 978-1-4398-1440-6, eBook ISBN: 978-1-4398-1442-0.

Multiscale cancer modeling.
Deisboeck TS, Wang Z, Macklin P, Cristini V.
Annu Rev Biomed Eng. 2011 Aug 15;13:127-55. doi: 10.1146/annurev-bioeng-071910-124729.

Integrative mathematical oncology.
Anderson AR, Quaranta V.
Nat Rev Cancer. 2008 Mar;8(3):227-34. doi: 10.1038/nrc2329.

Dissecting cancer through mathematics: from the cell to the animal model.
Byrne HM.
Nat Rev Cancer. 2010 Mar;10(3):221-30. doi: 10.1038/nrc2808.

In silico models of cancer.
Edelman LB, Eddy JA, Price ND.
Wiley Interdiscip Rev Syst Biol Med. 2010 Jul-Aug;2(4):438-59. doi: 10.1002/wsbm.75.

In silico cancer modeling: is it ready for prime time?
Deisboeck TS, Zhang L, Yoon J, Costa J.
Nat Clin Pract Oncol. 2009 Jan;6(1):34-42. doi: 10.1038/ncponc1237. Epub 2008 Oct 14.