Aarhus Building

Aarhus University Hospital

The department of Oncology hosts one of the largest oncology departments in Scandinavia, serving a catchment area of more than 1 mil. people. The Department of Oncology integrates the activities in the clinical department, the Department of Medical Physics and the Department of Experimental Clinical Oncology. The radiotherapy section includes 12 linear accelerators and 3 afterloaders, as well as 3 CT, 1 MRI, and 1 PET-CT scanner. The institution has played a very significant role in research and developments in radiation therapy and radiotherapy imaging, both on a national and international level. Conformal CT-based radiotherapy, intensity-modulated radiotherapy, MR-based brachytherapy, image guidance including daily cone-beam based set-up and stereotactic radiotherapy is thoroughly implemented in the clinic. Research programs are linked to the CT, MRI and PET/CT scanners in parallel with the clinical activities, and an interdisciplinary research MRI group embraces radiologists, oncologists, medical physicists and technologists. The Department of Experimental Clinical Oncology is conducting clinically oriented translational research in oncology, especially focusing on research related to radiotherapy and its application. The facilities include all the necessary equipment for radiobiological studies including cell culture facilities and laboratories for molecular biology and immunohistochemistry. The department hosts the radiation oncology research environment in Scandinavia. The research staff includes currently: 5 professors (2 radiation oncology, 1 clinical oncology, 1 medical physics, 1 psycho-oncology), 17 associate professors (7 full time, 10 part time (MD)), 9 assistant professors and postdocs, 34 PhD students, 10 master students.

Aarhus University

Aarhus University (Aarhus) has more than 10.000 members of staff and an annual enrolment of more than 38.000 students. In the latest rankings from the renowned British journal – the Times Higher Education Supplement, AU ranks among the best in Europe. Research programs include both bench science research and clinical research. Institute of Clinical Medicine has 1.140 persons affiliated. These are 20 professors, 80 clinical professors, 51 associate professors, 300 clinical or external associate professors, 29 postdocs, 200 Ph.D.-students.

URL

www.au.dk/en/ and www.auh.dk

Key publications

Tanderup K, Olsen DR, Grau C. Dose painting: art or science? Radiother Oncol 2006 June;79(3):245-8.
Assenholt MS, Petersen JB, Nielsen SK, Lindegaard JC, Tanderup K. A dose planning study on applicator guided stereotactic IMRT boost in combination with 3D MRI based brachytherapy in locally advanced cervical cancer. Acta Oncol 2008;47(7):1337-43.

Lindegaard JC, Tanderup K, Nielsen SK, Haack S, Gelineck J. MRI-guided 3D optimization significantly improves DVH parameters of pulsed-dose-rate brachytherapy in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 2008 July 1;71(3):756-64.

Tanderup K, Nielsen SK, Nyvang GB, Pedersen EM, Rohl L, Aagaard T et al. From point A to the sculpted pear: MR image guidance significantly improves tumour dose and sparing of organs at risk in brachytherapy of cervical cancer. Radiother Oncol 2010 February;94(2):173-80.

van der Heide UA, Houweling AC, Groenendaal G, Beets-Tan RG, Lambin P. Functional MRI for radiotherapy dose painting. Magn Reson Imaging 2012 November;30(9):1216-23.

van VM, van den Berg CA, Moman MR, van der Heide UA. Difficulties and potential of correlating local recurrences in prostate cancer with the delivered local dose. Radiother Oncol 2009 November;93(2):180-4.

Groenendaal G, van VM, Pereboom SR, Poelma-Tap D, Korporaal JG, Monninkhof E et al. The effect of hormonal treatment on conspicuity of prostate cancer: implications for focal boosting radiotherapy. Radiother Oncol 2012 May;103(2):233-8.

Thornqvist S, Bentzen L, Petersen JB, Hysing LB, Muren LP. Plan robustness of simultaneous integrated boost radiotherapy of prostate and lymph nodes for different image-guidance and delivery techniques. Acta Oncol 2011 August;50(6):926-34.

Thornqvist S, Muren LP, Bentzen L, Hysing LB, Hoyer M, Grau C et al. Degradation of target coverage due to inter-fraction motion during intensity-modulated proton therapy of prostate and elective targets. Acta Oncol 2013 April;52(3):521-7.

Thor M, Apte A, Deasy JO, Muren LP. Statistical simulations to estimate motion-inclusive dose-volume histograms for prediction of rectal morbidity following radiotherapy. Acta Oncol 2013 April;52(3):666-75.

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